Issue 1, 2007
From the journal:

Green Chemistry

Electrosynthesis of phenyl-2-propanone derivatives from benzyl bromides and acetic anhydride in an unsupported micro-flow cell electrolysis process†

Ping He,a   Paul Watts,a   Frank Markenb  and  Stephen J. Haswell*a  

* Corresponding authors

a Department of Chemistry, University of Hull, Hull, UK
E-mail: s.j.haswell@hull.ac.uk

b Department of Chemistry, University of Bath, Bath, UK

Abstract

A simple process for the synthesis of phenyl-2-propanone is described based on a one-step electrochemical acylation reaction, involving the direct electroreductive coupling of benzyl bromides and acetic anhydride in a micro-flow electrolysis cell, equipped with micro-gap Pt electrodes. The technique offered yields typically in excess of 80% with corresponding high levels of product selectivity. The electrochemical process was also scaled-up by connecting four identical micro electrochemical cells in parallel to increase product throughput.

Graphical abstract: Electrosynthesis of phenyl-2-propanone derivatives from benzyl bromides and acetic anhydride in an unsupported micro-flow cell electrolysis process

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Article information

DOI
https://doi.org/10.1039/B610415K
Article type
Communication
Submitted
20 Jul 2006
Accepted
26 Oct 2006
First published
03 Nov 2006

Green Chem., 2007,9, 20-22

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Electrosynthesis of phenyl-2-propanone derivatives from benzyl bromides and acetic anhydride in an unsupported micro-flow cell electrolysis process

P. He, P. Watts, F. Marken and S. J. Haswell, Green Chem., 2007, 9, 20 DOI: 10.1039/B610415K

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